In 1936, Thaden, and co-pilot Blanche Noyes, became the first women to win the Bendix Transcontinental Air Race. She won aviation's highest honor given a female pilot, and the Harmon Trophy, a year later.
Louise married Herbert Von Thaden, a former United States Army pilot and Engineer, in 1928. They had two children, Bill and Pat. She authored her memories in High, Wide, and Frightened, as well as many other articles about aviation. On November 9, 1979, Louise M. Thaden died of a heart attack in High Point, NC.